Chronic Fatigue Syndrome (CFS)

CFS is not a mystery, but the consequence of chronic infections by intracellular bacteria such as rickettsiae.

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What is CFS / ME?

CFS (Chronic Fatigue Syndrome), also known as Myalgic Encephalomyelitis (ME), refers to a state of persistent, severe exhaustion without adequate other explanation. Affected individuals feel permanently ill, powerless and mentally as well as physically exhausted, even after adequate sleep.

Our View:

CFS arises from a kind of cellular energy deficiency state, caused by invading intracellular bacteria such as rickettsiae, which disrupt cellular metabolism.

Cellular Anoxia

The Effects of Intracellular Bacteria

Oxygen deficiency in cellscritical
Glucose depletionhigh
Electrolyte disordershigh
Cholesterol shockmedium
CFS is not 'giving up'. It is the daily struggle of a body crushed by invisible burdens. We fight for the recognition of this biological reality.
Teresa Maria TaddonioPatient Advocate & Chairperson

Main Symptoms

CFS manifests through characteristic symptoms that severely impact patients' lives.

Persistent fatigue

Severity: high

Post-Exertional Malaise

Severity: critical

Concentration disorders

Severity: high

Muscle pain

Severity: medium

Sleep disorders

Severity: high

Headaches

Severity: medium

Scientific Evidence

Recent research supports the infection hypothesis in CFS.

Prof. Tim Roberts Study

University of Newcastle, Australia

Characteristic metabolic profiles in CFS patients suggesting the body is fighting a chronic infection.

  • Altered blood lipid levelsConfirmed
  • Elevated amino acids in urineConfirmed
  • Catabolic metabolic stateConfirmed

Dr. Cecile Jadin Study

South Africa - 3000 CFS patients

Rickettsia infections detected in CFS patients and successfully treated with special antibiotics (tetracyclines).

Treatment Success

Significant improvement of symptoms through antimicrobial therapy

Behind the diagnosis of CFS often lies an undetected chronic infection. We must look deep to find the true causes of fatigue.
Dr. med. Philippe BotteroInfectious Disease Researcher

Possible Pathogens

Various intracellular pathogens can trigger CFS.

Rickettsia species

25-30%

Intracellular bacteria

Disease mechanism:

Vascular damage and immune deficiency

Borrelia burgdorferi

20-25%

Spirochete bacteria

Disease mechanism:

Neurological and systemic inflammation

Epstein-Barr Virus

15-20%

Herpes virus

Disease mechanism:

Immune system exhaustion

Chlamydia pneumoniae

10-15%

Intracellular bacteria

Disease mechanism:

Chronic inflammatory response

Disease Course Without Treatment

Untreated CFS can lead to various chronic diseases.

Neurological

  • Multiple Sclerosis
  • ALS
  • Parkinson's
  • Autism

Autoimmune

  • Lupus
  • Rheumatoid Arthritis
  • Thyroid Inflammation

Cardiovascular

  • Myocarditis
  • Vascular Damage

Other

  • Fibromyalgia
  • Crohn's Disease
  • Cancer

Important Notice

CFS is reversible if the underlying infection is found and treated early. When the triggering infections are found and treated, health status can improve dramatically.

CFS and Long COVID

Long COVID shows strong similarities to classic ME/CFS and confirms the infection hypothesis.

Similar symptoms

Long COVID and ME/CFS show striking similarities in symptoms: extreme fatigue, cognitive impairment, and post-exertional malaise.

Measurable markers

Both conditions show similar biomarkers such as elevated inflammatory markers, disrupted cellular energy production, and autoimmune reactions.

New therapies

Long COVID research opens new treatment pathways for both conditions and confirms the infection hypothesis.

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